Importantly, the QMP-engineered GLP-1 albumin fusion did not only display improved PK properties, but also demonstrated a prolonged therapeutic effect in healthy human FcRn Tg32 mice challenged with a high dose of glucose
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Then, 10 l aliquots of these reactions were directly added to 90 l ultrafiltered flavan-3,3,4-triol ( 4 ) to initiate the second step of the two-step in vitro assays with 3,4- cis -leucocyanidin ( 6 ) as described below